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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

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Viral encephalitis and atherothrombotic stroke.

Ana Maria Garcia¹, Jose Antonio Egido, Patricia Simal

¹Stroke Unit, Department of Neurology, Hospital Clinico San Carlos, Madrid, Spain.

BMJ Case Reports

|November 6, 2012

Summary

This case study highlights a rare stroke-like presentation of herpetic encephalitis (HE). Early diagnosis and antiviral treatment led to a good recovery, emphasizing HE

Area of Science:

Neurology
Infectious Diseases
Vascular Neurology

Background:

Viral encephalitis typically presents with fever, but stroke-like symptoms are uncommon.
Herpetic encephalitis (HE) can mimic cerebrovascular events, posing diagnostic challenges.
Distinguishing between stroke and encephalitis is crucial for appropriate management.

Observation:

A patient presented with acute stroke symptoms (right middle cerebral artery syndrome) without fever.
Initial improvement occurred after thrombolytic therapy for suspected stroke.
Recurrence of neurological deficits accompanied by fever led to reconsidering the diagnosis.

Findings:

Herpetic encephalitis (HE) was diagnosed despite the initial stroke-like presentation.
The patient showed a significant positive response to antiviral therapy.

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The case raises questions about whether the HE had an unusual stroke-like onset or if a stroke triggered delayed HE.

Implications:

Clinicians should consider herpetic encephalitis in patients with stroke-like presentations, even without fever.
Prompt diagnosis and initiation of antiviral treatment are crucial for favorable outcomes in HE.
This case expands the known clinical spectrum of herpetic encephalitis and its potential triggers.