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Updated: May 17, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
2-Carbamoyl-3,4,5,6-tetra-fluoro-benzoic acid
Tao Lu1, Xiao-Jian Liao, Yuan-Wei Liang
1Department of Chemistry, Jinan University, Guangzhou 510632, People's Republic of China.
Abstract:
In the title compound, C(8)H(3)F(4)NO(3), the carb-oxy group lies nearly in the plane of the ring with a C-C-C-O torsion angle of -10.5 (4)°. The carbamoyl group is almost perpendic-ular to the benzene ring [C-C-C-O torsion angle = 82.2 (4) °]. In the crystal, molecules are linked via O-H⋯O and N-H⋯O hydrogen bonds involving the carbamoyl and carb-oxy groups.
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