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Sorbicitrinols A and B, Two Sorbicillinoids with Unprecedented Skeletons Uncovered from Sponge-Derived Fungus
Ze-Bin Chen1, Hui-Xian Liang1, Wan-Ying Guo1
1Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, P. R. China.
Abstract:
Sorbicitrinol A (1) and its biosynthetic precursor sorbicitrinol B (2), two novel sorbicillinoids with unprecedented skeletons, were isolated from the sponge-derived fungus Penicillium sp. by molecular networking. Their structures were identified by spectroscopic analyses and quantum chemistry. Both of them exhibited an innovative fusion pattern of sorbicillinol and a citrinin derivative. Compound 1 was the first example of a sorbicillinoid featuring the unique cage-like 2,5-dioxa-pentacyclo[10.4.03,11.04,8.04,15]tetradecane scaffold. Plausible biogenetic pathways were proposed, and their antitumor and antifungal activities were also evaluated.
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