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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

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Related Experiment Video

Updated: May 17, 2026

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

Quantitative (90)Y image reconstruction in PET.

Kathy Willowson1, Nicholas Forwood, Bjoern W Jakoby

  • 1Institute of Medical Physics, University of Sydney, Camperdown, Australia.

Medical Physics
|November 7, 2012
PubMed
Summary
This summary is machine-generated.

Quantitative Yttrium-90 (90Y) Positron Emission Tomography (PET) imaging accurately measures radioactivity in liver cancer treatment. This method confirms microsphere localization and aids in calculating absorbed dose, improving treatment efficacy.

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Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
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Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

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Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
10:21

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Published on: August 8, 2019

Area of Science:

  • Nuclear Medicine
  • Medical Imaging
  • Radiotherapy

Background:

  • Positron emission tomography (PET) imaging is crucial for confirming the localization of Yttrium-90 ((90)Y) microspheres in liver cancer treatment.
  • Accurate quantification of (90)Y PET data is essential for effective treatment planning and dose assessment.

Purpose of the Study:

  • To evaluate the quantitative accuracy of (90)Y PET data acquired on a modern time-of-flight (TOF) extended axial field-of-view PET/CT scanner.
  • To assess the impact of reconstruction parameters and TOF on quantitative measurements.

Main Methods:

  • Utilized an International Electrotechnical Commission (IEC) body phantom with varying sphere sizes containing (90)Y solution.
  • Acquired multiple PET studies over time, evaluating Ordered Subset Expectation Maximization (OSEM) reconstruction parameters and TOF effects.
  • Compared measured activity and concentration to expected values and assessed partial volume effects.

Main Results:

  • OSEM iteration increases negatively impacted image data and hot concentration measures.
  • Average differences between measured and true total activity and background concentration were +5%.
  • Hot-sphere concentration was consistently underestimated by 8-23% depending on the volume of interest (VOI) definition. TOF improved hot-sphere contrast but worsened background variability.

Conclusions:

  • Quantitative (90)Y PET/CT imaging with TOF provides consistent and acceptable measures of total activity and radionuclide concentration.
  • The method is suitable for measuring radioactivity delivered during (90)Y therapy and has potential for absorbed dose calculation.