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Dynamic SPECT Assessment of Hepatic Function in Patients With Liver Disease: A Systematic Review and Meta-Analysis
Bader Aloufi1,2, Roger Fulton1,3, Kathy Willowson4,5
1Discipline of Medical Imaging Science, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Dynamic Single Photon Emission Computed Tomography (dynSPECT) effectively assesses liver function, showing comparable results to traditional tests. This advanced imaging offers valuable insights for patients with liver disease.
Area of Science:
- Medical Imaging
- Nuclear Medicine
- Hepatology
Background:
- Dynamic Single Photon Emission Computed Tomography (dynSPECT) is an advanced functional imaging technique.
- Its application in liver imaging remains underexplored.
- This review evaluates dynSPECT's role in assessing hepatic function.
Purpose of the Study:
- To investigate the effectiveness of dynSPECT in evaluating liver function.
- To compare dynSPECT results with established liver function tests and scoring systems.
Main Methods:
- A systematic literature review was conducted following PRISMA guidelines.
- Searches included MEDLINE, PubMed, Scopus, Embase, IEEE, and Web of Science up to December 2025.
- Included studies were assessed for bias using the QUADAS-2 tool.
Main Results:
- Sixteen studies with 715 participants (87% with hepatic diseases) were included.
- Meta-analysis showed significant correlations between dynSPECT measures and Hepaplastin, Indocyanine Green (ICG), and Bilirubin levels.
- dynSPECT parameters correlated significantly with Child-Pugh, MELD, and histologic activity index (HAI) scores (p < 0.001).
Conclusions:
- dynSPECT is a valuable tool for assessing liver function in patients with hepatic dysfunction.
- Its performance is comparable to standard clinical laboratory tests and scoring systems.
- dynSPECT offers a promising approach for liver disease assessment.
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