Related Experiment Videos
Altered hemodynamic response to isosorbide dinitrate in essential hypertension
B M Pannier1, T Kando, A A Safarian
1Department of Internal Medicine, Broussais Hospital, Paris, France.
Journal of Clinical Pharmacology
|February 1, 1990
Summary
Isosorbide dinitrate increases aortic diameter and arterial distensibility in both healthy individuals and those with hypertension. However, its blood pressure-lowering effects are more pronounced in hypertensive patients.
Area of Science:
- Cardiovascular Physiology
- Pharmacology
- Hypertension Research
Background:
- Nitrates are known vasodilators affecting various blood vessels.
- Limited in vivo data exists on nitrate effects on human hypertensive aortas.
Purpose of the Study:
- To investigate the in vivo effects of isosorbide dinitrate on aortic properties in hypertensive and normotensive individuals.
- To compare the vasodilator response to nitrates in essential hypertension versus normal physiology.
Main Methods:
- Acute oral administration of 20 mg isosorbide dinitrate.
- Noninvasive assessment of blood pressure, pulse wave velocity, and aortic arch diameter via echocardiography.
- Measurements taken in 12 hypertensive and 9 normotensive subjects before and 3 hours post-administration.
Main Results:
- Isosorbide dinitrate decreased systolic and pulse pressure in normotensives; it reduced systolic, diastolic, mean, and pulse pressure in hypertensives.
- Pulse wave velocity significantly decreased, and aortic arch diastolic diameter increased markedly in both groups.
- Enhanced arterial distensibility was observed in both populations.
Conclusions:
- Isosorbide dinitrate improves aortic distensibility and diameter in both healthy and hypertensive individuals.
- The significant reduction in mean arterial pressure solely in hypertensives suggests altered vasodilator response not mediated by the endothelium.