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Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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The two main cell types that...
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Related Experiment Video

Updated: May 17, 2026

A Neurosphere Assay to Evaluate Endogenous Neural Stem Cell Activation in a Mouse Model of Minimal Spinal Cord Injury
09:08

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Published on: September 13, 2018

Neural stem cells and stroke.

Dah-Ching Ding1, Chen-Huan Lin, Woei-Cherng Shyu

  • 1Department of Obstetrics and Gynecology, Buddhist Tzu Chi General Hospital, Tzu Chi University, Hualien, Taiwan, ROC.

Cell Transplantation
|November 7, 2012
PubMed
Summary
This summary is machine-generated.

Neural stem cells (NSCs) offer a promising therapy for acute ischemic stroke by leveraging the brain's natural repair mechanisms. This review explores preclinical studies on NSC therapy, focusing on neurogenesis and cell integration for stroke recovery.

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Last Updated: May 17, 2026

A Neurosphere Assay to Evaluate Endogenous Neural Stem Cell Activation in a Mouse Model of Minimal Spinal Cord Injury
09:08

A Neurosphere Assay to Evaluate Endogenous Neural Stem Cell Activation in a Mouse Model of Minimal Spinal Cord Injury

Published on: September 13, 2018

Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain
06:12

Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain

Published on: January 27, 2022

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Stroke Research

Background:

  • Acute ischemic stroke disrupts neuronal circuitry and the blood-brain barrier, leading to functional deficits.
  • Current thrombolytic therapies have limited accessibility, necessitating alternative treatment strategies.
  • The brain possesses endogenous repair mechanisms, including neural stem cell (NSC) proliferation and neurogenesis.

Purpose of the Study:

  • To review current preclinical cell therapies for stroke.
  • To focus on neurogenesis within the subventricular zone (SVZ) and dentate gyrus.
  • To examine recruitment cues that facilitate NSC homing and integration into damaged brain tissue.

Main Methods:

  • Review of preclinical studies on neural stem cell (NSC) therapy for stroke.
  • Analysis of neurogenesis in the subventricular zone (SVZ) and dentate gyrus.
  • Investigation of factors influencing NSC homing and integration.

Main Results:

  • The subventricular zone (SVZ) microenvironment supports NSC proliferation, self-renewal, and multipotency.
  • Ischemic stroke triggers endogenous neurogenesis, indicating brain plasticity.
  • NSC homing and integration to damaged areas are complex processes influenced by specific cues.

Conclusions:

  • Neural stem cells (NSCs) represent a promising therapeutic avenue for stroke.
  • Understanding neurogenesis and NSC recruitment is crucial for developing effective cell-based stroke treatments.
  • Further research into NSC homing and integration mechanisms can optimize cell therapy strategies.