Related Experiment Video
Updated: May 17, 2026

Establishment of a Mouse Model with Cough Hypersensitivity via Inhalation of Citric Acid
Published on: January 10, 2025
Psychogenic cough: a diagnosis of exclusion
Roberto Velasco-Zúñiga1, Helvia Benito-Pastor, Pablo Del Villar-Guerra
1Pediatric Emergency Teaching Hospital Río Hortega, Valladolid, Spain. quetzal1980@yahoo.es
Insights
This case study highlights psychogenic cough, a condition often mistaken for asthma. Recognizing specific symptoms and focusing on behavioral therapies can effectively resolve persistent coughs in children.
Area of Science:
- Pediatrics
- Psychosomatic Medicine
- Respiratory Medicine
Background:
- Cough is a frequent respiratory symptom leading to medical consultations.
- Persistent or difficult-to-control cough in children can be challenging to diagnose and manage.
- Psychogenic cough should be considered in the differential diagnosis of chronic cough.
Observation:
- An 11-year-old girl presented with a 4-hour episode of constant, intense cough.
- The cough showed a unique pattern, decreasing with distraction and worsening upon mention of the word 'cough'.
- Initial pharmacological treatments provided only transient relief, suggesting a non-organic cause.
Findings:
- The patient's cough significantly improved with midazolam infusion and resolved after she fell asleep.
- Diagnostic criteria for psychogenic cough include cough occurring only when awake, with normal respiratory function tests and imaging.
- The case underscores the importance of identifying psychogenic cough to prevent misdiagnosis and inappropriate treatment.
Implications:
- Clinicians should consider psychogenic cough in cases of unexplained persistent cough, especially when unresponsive to standard treatments.
- Accurate diagnosis of psychogenic cough can prevent unnecessary medication and guide appropriate therapeutic interventions.
- Cognitive-behavioral therapies are crucial for managing psychogenic cough by addressing the underlying habit.
Abstract:
Cough is the most common respiratory symptom and a common reason for consultation in both primary care and emergency departments, as a result of family concerns. We report an 11-year-old girl who complains of constant cough episode for 4 hours without any rest. After sequential treatment with nebulized salbutamol and budesonide, dexamethasone, codeine, and midazolam, the patient showed transient improvement, with cough disappearing altogether, but 10 minutes later, it started over with the same intensity from the beginning. When she got distracted and talked, the access decreased, starting again when the word "cough" or similar terms were mentioned in front of her. She remained asymptomatic for 2 hours, after which her symptoms began similarly to the initial, coinciding with taking 1 tablet of clarithromycin, so it was decided to start a continuous infusion of midazolam, with the cough disappearing completely after 15 minutes of starting the infusion. One hour after starting the infusion, the child fell asleep. At waking, the cough had disappeared. She continued treatment with oral codeine for 3 days, showing no relapse. It is important to include psychogenic cough in the differential diagnosis of persistent or recurrent chronic cough and asthma that is difficult to control and communicate that diagnostic criteria are based on indicative symptoms (cough access only when awake), with normal radiology, spirometry, and bronchoscopy, to avoid misdiagnosis and inadequate pharmacological actions. Successful treatment is based on recognizing the underlying cause and use of different forms of cognitive-behavioral therapies that aim to break the habit.
Related Concept Videos
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Medical History
Chronic Obstructive Pulmonary Disease-I: Introduction
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Chronic Obstructive Pulmonary Disease I: Introduction
COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Chronic Obstructive Pulmonary Disease
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...

