Related Experiment Video
Updated: May 17, 2026

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
Published on: December 23, 2022
[Primary melanoma of the esophagus]
Rakel Cardeña1, Victor Yep-Gamarra, Jean Donet-Mostacero
1Servicio de Anatomía Patológica del Hospital Luís Heysen Incháustegui Es salud Chiclayo-Perú.
Abstract:
Primary malignant melanoma of the esophagus is a rare, aggressive and poor-prognostic neoplasm, usually detected in late stages. Surgery (esophagectomy) is the treatment of choice when operable and the only factor that improves the disease prognosis is the detection of the lesions in early stages and the recognition of non-typical lesions. Most commonly, Melanoma lesions appear as large masses with proliferative, ulcerated and pigmented aspect. We report a clinical case whose endoscopic presentation was an elevated, protruding and sessile lesion (Paris Classification Type 0- Is), amelanocytic, size of 4mm, smooth surface, pink and with regular borders (mucosa of tumor with a normal esophagic mucosa appearance). This lesion initially could not be identified because the patient was admitted due to upper gastrointestinal bleeding caused by peptic esophagitis Grade D according to Los Angeles Classification. After histological analysis and immunohistochemistry of the lesion, melanoma was diagnosed. No skin, mucous or ocular lesions were found and multislice spiral computed tomography of thorax and abdomen did not show any metastasis.
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