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Notch pathway is involved in high glucose-induced apoptosis in podocytes via Bcl-2 and p53 pathways

Feng Gao1, Min Yao, Yonghong Shi

  • 1Department of Pathology, Hebei Medical University, Shijiazhuang, Hebei 050017, China.

Journal of Cellular Biochemistry
|November 7, 2012
PubMed

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Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
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