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Updated: May 17, 2026

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
Published on: December 23, 2016
Tracking the bioreduction of disulfide-containing cationic dendrimers
Lorine Brülisauer1, Nadia Kathriner, Mark Prenrecaj
1Swiss Federal Institute of Technology Zurich (ETHZ), Department of Chemistry and Applied Biosciences, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland.
Abstract:
Disulfides enhance the transfection efficacy and reduce the toxicity of cationic gene delivery polymers. A quantitative analysis is provided of the bioreduction of a dynamic bioreducible dendritic polycationic probe in four cell lines. Such knowledge is indispensible for understanding and optimizing bioreducible drug and gene delivery systems.
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