Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetic Models: Overview01:20

Pharmacokinetic Models: Overview

Pharmacokinetic models utilize mathematical analysis to achieve a detailed quantitative understanding of a drug's life cycle within the body. They are instrumental in simulating a drug's pharmacokinetic parameters, predicting drug concentrations over time, optimizing dosage regimens, linking concentrations with pharmacologic activity, and estimating potential toxicity.
There are three primary types of models: empirical, compartment, and physiological. Empirical models, with minimal assumptions,...
Nonlinear Pharmacokinetics: Overview01:19

Nonlinear Pharmacokinetics: Overview

Nonlinear or dose-dependent pharmacokinetics is a phenomenon that occurs when the pharmacokinetic parameters of certain drugs deviate from linear pharmacokinetics at higher doses. These drugs do not follow the expected first-order kinetics, where the rate of drug elimination is directly proportional to the drug concentration. Instead, they exhibit a nonlinear relationship, which can be attributed to several factors.
Nonlinearity can arise due to the saturation of plasma protein-binding or...
Pharmacokinetic–Pharmacodynamic Relationship: Problems01:24

Pharmacokinetic–Pharmacodynamic Relationship: Problems

The empirical approach to drug therapy optimization relies on correlating pharmacological response with administered dosage. Such an approach can be costly, time-consuming, and often yields poor correlation due to variables like formulation factors and drug elimination characteristics. A more precise approach correlates response with plasma drug concentration or the amount of drug in the body, rather than dosage. This is achieved through pharmacokinetic-pharmacodynamic (PK/PD) modeling, which...
Pharmacokinetics: Overview01:10

Pharmacokinetics: Overview

Pharmacokinetics is a scientific discipline that focuses on the journey of a drug within the body, encompassing four key stages: absorption, distribution, metabolism, and elimination. The first stage, absorption, involves the drug's transfer into the bloodstream. Several factors dictate the extent and speed of this process. For example, the liver often metabolizes oral drugs before they reach systemic circulation, leading to only partial absorption. In contrast, intravenous (IV) administration...
Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance01:07

Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance

Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
A recent model describes pravastatin's hepatobiliary excretion, mediated...
Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis00:59

Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis

Noncompartmental analyses offer an alternative method for describing drug pharmacokinetics without relying on a specific compartmental model. In this approach, the drug's pharmacokinetics are assumed to be linear, with the terminal phase log-linear. This assumption allows for simplified analysis and interpretation of the drug's behavior in the body.
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This relationship...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fungal Nails? DNA Facts Challenge Dystrophic Etiology.

Journal of the American Podiatric Medical Association·2021
Same author

A review of iodine-based compounds, with a focus on biofilms: results of an expert panel.

Journal of wound care·2020
Same author

Treatment Options to Manage Wound Biofilm.

Advances in wound care·2014
Same author

Introduction to pulmonary medicine: part II.

Journal of pharmacy practice·2013
Same author

Introduction to pulmonary medicine: part 1.

Journal of pharmacy practice·2012
Same author

Use of cetirizine in a 23-month-old male causes insomnia.

Southern medical journal·2010

Related Experiment Video

Updated: May 17, 2026

Improving Student Outcomes with an Adaptable Molecular Cloning Course-Based Undergraduate Research Experience
10:17

Improving Student Outcomes with an Adaptable Molecular Cloning Course-Based Undergraduate Research Experience

Published on: November 15, 2024

Small-team active learning in an integrated pharmacokinetics course series.

Curtis E Jones1, S Craig Dyar, Andrea L McKeever

  • 1School of Pharmacy, South University, Savannah, GA, USA.

American Journal of Pharmaceutical Education
|November 7, 2012
PubMed
Summary

This pharmacokinetics curriculum improved students' confidence in applying concepts. While team collaboration anxiety decreased, peer teaching anxiety persisted, impacting critical evaluation skills.

Keywords:
active learningpharmacokineticsproblem-based learningteam learning

Related Experiment Videos

Last Updated: May 17, 2026

Improving Student Outcomes with an Adaptable Molecular Cloning Course-Based Undergraduate Research Experience
10:17

Improving Student Outcomes with an Adaptable Molecular Cloning Course-Based Undergraduate Research Experience

Published on: November 15, 2024

Area of Science:

  • Pharmacology Education
  • Active Learning Strategies
  • Curriculum Development

Background:

  • Traditional pharmacokinetics education often struggles with student engagement and concept application.
  • Implementing active learning methodologies is crucial for enhancing understanding in complex scientific subjects.
  • Assessing student perceptions is vital for refining educational approaches.

Purpose of the Study:

  • To implement and evaluate a pharmacokinetics curriculum utilizing small-team active learning.
  • To assess student perceptions regarding teamwork, peer teaching, and concept application within the curriculum.
  • To determine the impact of the active learning approach on students' confidence and critical evaluation skills.

Main Methods:

  • A pharmacokinetics course was designed using a lecture followed by problem-based learning (PBL) small-team sessions.
  • Faculty facilitated active learning environments through classroom and PBL discussions.
  • Anonymous pre- and post-course surveys were administered to gauge student perceptions and anxiety levels.

Main Results:

  • Student anxiety related to small-team collaboration significantly decreased from 67% to 44%.
  • A high percentage of students (80%) reported persistent anxiety regarding peer teaching and receiving information from peers.
  • The curriculum positively impacted students' ability to apply concepts to case studies but had minimal effect on critical evaluation and presentation skills.

Conclusions:

  • The team-based active learning structure enhances student comfort and confidence in applying pharmacokinetics to therapeutic scenarios.
  • Further refinement is needed to address student anxiety associated with peer teaching within active learning pharmacokinetics curricula.
  • The study highlights the benefits and challenges of integrating active learning in specialized scientific education.