Related Experiment Video
Updated: May 17, 2026
05:39
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
Published on: May 16, 2025
Erythema elevatum diutinum associated with scleritis
Smitha Prabhu1, Shrutakirthi D Shenoi, Pallav S Kishanpuria
1Department of Dermatology and Venereology, Kasturba Medical College, Manipal University, Manipal, India.
Indian Dermatology Online Journal
|November 7, 2012
Summary
Erythema elevatum diutinum (EED), a rare vasculitis, often links to HIV. This case highlights EED presenting with skin nodules and scleritis, successfully treated with Dapsone.
Area of Science:
- Dermatology
- Rheumatology
- Ophthalmology
Background:
- Erythema elevatum diutinum (EED) is a rare chronic leukocytoclastic vasculitis.
- EED is increasingly associated with HIV infection.
- It typically presents with skin lesions and arthralgia.
Observation:
- A 45-year-old male presented with joint pain, palm/sole nodules, and ocular symptoms.
- Histopathological examination confirmed EED and scleritis.
- The patient had no known HIV infection or other reported associations.
Findings:
- Dapsone monotherapy led to complete resolution of both skin and ocular symptoms.
- This case underscores the efficacy of Dapsone in managing EED with scleritis.
- The report details a rare presentation of EED without typical associated conditions.
Implications:
- Highlights Dapsone as an effective monotherapy for EED and associated scleritis.
- Suggests considering EED in patients with unexplained skin nodules and ocular inflammation.
- Broadens understanding of EED's clinical spectrum and treatment responses.
Related Concept Videos
01:25Endocarditis II: Clinical Features of Infective Endocarditis
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
01:23Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
01:28Graves' Disease I: Introduction
Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
01:19Hypersensitivity Reactions: Immune-Complex Reactions
Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
01:20Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
01:30Drug Toxicity: Allergic Reactions
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...