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Updated: May 17, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
Published on: March 7, 2025
Rheumatological manifestations occurring in patients with diabetes mellitus
1Department of Internal Medicine, Hospital de San Juan, Alicante, Spain. sara23x@hotmail.com
Musculoskeletal (MSK) issues are common in diabetes mellitus (DM). Managing blood glucose levels may help reduce the risk of these common MSK complications in patients with DM.
Area of Science:
- Endocrinology
- Rheumatology
- Internal Medicine
Background:
- Diabetes mellitus (DM) is a complex metabolic disorder with various systemic complications.
- Musculoskeletal (MSK) manifestations are increasingly recognized as a significant comorbidity in patients with DM.
Purpose of the Study:
- To review the existing evidence on the association between musculoskeletal manifestations and diabetes mellitus.
- To highlight the prevalence and nature of MSK complications in diabetic patients.
Main Methods:
- A systematic literature review was conducted using PubMed.
- Searched for articles published between January 2003 and August 2011.
- Keywords included 'musculoskeletal manifestations' and 'diabetes mellitus'.
Main Results:
- Musculoskeletal manifestations are relatively common in individuals with diabetes mellitus.
- The duration of diabetes mellitus often correlates with the development of certain MSK features.
- Distinguishing between Type 1 and Type 2 DM for MSK manifestations was challenging due to reporting inconsistencies.
Conclusions:
- Patients with diabetes mellitus exhibit an increased prevalence of several MSK manifestations.
- Awareness of these MSK complications is crucial for effective patient management.
- Improved glycemic control may play a role in mitigating MSK complications associated with diabetes.
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