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Heart failure in a woman with SLE, anti-phospholipid syndrome and Fabry's disease
A Nandagudi1, E C Jury, D Alonzi
1Department of Rheumatology, University College Hospital, UK.
Abstract:
We describe a female patient with systemic lupus erythematosus (SLE) also diagnosed with Fabry's disease and anti-phospholipid antibody syndrome (APS). SLE and Fabry's disease are both systemic diseases with variable clinical presentations. Recent studies have shown a relatively high incidence of late onset Fabry's disease in female heterozygous individuals, suggesting that this condition could be under-diagnosed. We discuss a possible association between SLE and Fabry's disease and consider the role of lipid abnormalities in the pathogenesis of SLE.
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