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Related Concept Videos

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

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Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
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There are many research methods available to psychologists in their efforts to understand, describe, and explain behavior and the cognitive and biological processes that underlie it.

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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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[Cherubism: a case followed for 18 years].

J-L Ducours1, M Ducours

  • 1Service chirurgie plastique reconstructrice esthétique et maxillo-faciale, clinique Esquirol-Saint-Hilaire, 1, rue du Dr et Mme Delmas, BP 19, 47002 Agen cedex, France. jean-luc.ducours@omega.amsh.org

Annales De Chirurgie Plastique Et Esthetique
|November 8, 2012
PubMed
Summary

Cherubism, a rare genetic bone disease, causes facial swelling. Diagnosis involves clinical, radiological, and definitive histological examination of bone tissue.

Area of Science:

  • Genetics
  • Pathology
  • Oral and Maxillofacial Surgery

Background:

  • Cherubism is a rare, benign genetic bone disease primarily affecting facial bones, particularly the mandible.
  • The condition presents with characteristic facial swelling, often leading to diagnostic challenges in young patients.

Observation:

  • A longitudinal case study details a patient from age 4.5 to 22, illustrating surgical treatment progression.
  • Clinical and radiological examinations are crucial, though histological confirmation is definitive for diagnosis.

Findings:

  • Histological examination reveals dense, vascularized connective tissue with multinucleated giant cells, devoid of atypia.
  • Differential diagnosis requires excluding other facial bone diseases through comprehensive evaluation.

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Implications:

  • Treatment remains controversial, balancing therapeutic abstention with surgical intervention for functional and aesthetic concerns.
  • Early recognition of cherubic features and prompt histological analysis are vital for accurate diagnosis and management.