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Updated: May 17, 2026

Crystallizing Membrane Proteins for Structure Determination using Lipidic Mesophases
Published on: November 21, 2010
Structure-function insights of membrane and soluble proteins revealed by electron crystallography
Tina M Dreaden1, Bharanidharan Devarajan, Bridgette A Barry
1School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA.
Abstract:
Electron crystallography is emerging as an important method in solving protein structures. While it has found extensive applications in the understanding of membrane protein structure and function at a wide range of resolutions, from revealing oligomeric arrangements to atomic models, electron crystallography has also provided invaluable information on the soluble α/β-tubulin which could not be obtained by any other method to date. Examples of critical insights from selected structures of membrane proteins as well as α/β-tubulin are described here, demonstrating the vast potential of electron crystallography that is first beginning to unfold.
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