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Antibodies from colostrum in oral immunotherapy
W Stephan1, H Dichtelmüller, R Lissner
1Biotest Pharma GmbH, Forschungsabteilung, Frankfurt.
Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Fur Klinische Chemie Und Klinische Biochemie
|January 1, 1990
Summary
Oral bovine colostrum immunoglobulin concentrate offers a potent treatment for severe diarrhea. This preparation effectively neutralizes bacterial toxins and antibodies, proving beneficial for conditions like AIDS-related diarrhea.
Area of Science:
- Immunology
- Gastroenterology
- Bovine Colostrum Research
Background:
- Severe diarrhea poses significant health challenges, particularly in immunocompromised individuals.
- Bovine colostrum is a rich source of immunoglobulins and growth factors.
- Existing treatments for severe diarrhea may have limitations in efficacy or tolerability.
Purpose of the Study:
- To develop and evaluate an oral immunoglobulin preparation from bovine colostrum.
- To assess the preparation's efficacy in treating severe diarrhea, including in patients with Acquired Immunodeficiency Syndrome (AIDS).
- To characterize the preparation's antibacterial antibody and toxin-neutralizing capacities.
Main Methods:
- Pooling colostrum from over 100 bovine donors.
- Processing the colostrum into a spray-dried immunoglobulin preparation.
- Assessing antibacterial antibody titers and bacterial toxin neutralization capacity.
- Clinical evaluation of the preparation's tolerability and efficacy in severe diarrhea cases.
Main Results:
- The oral immunoglobulin preparation demonstrated high antibacterial antibody titers.
- The preparation effectively neutralized bacterial toxins.
- It was well-tolerated and highly effective in treating severe diarrhea, including in AIDS patients.
- The spray-dried preparation is stable when stored at 2-8 degrees C.
Conclusions:
- Oral bovine colostrum immunoglobulin concentrate is a promising therapeutic agent for severe diarrhea.
- The preparation's high antibody and toxin-neutralizing capacity contributes to its effectiveness.
- Its stability and tolerability make it a viable option for managing severe gastrointestinal infections.