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Preparing a 68Ga-labeled Arginine Glycine Aspartate (RGD)-peptide for Angiogenesis
Published on: January 7, 2019
Development of NGR peptide-based agents for tumor imaging
Rongsheng E Wang1, Youhong Niu, Haifan Wu
1Department of Chemistry, Washington University in St. Louis St. Louis, MO 63130, USA.
American Journal of Nuclear Medicine and Molecular Imaging
|November 8, 2012
Summary
The Asn-Gly-Arg (NGR) tripeptide targets tumor vasculature and cells for molecular imaging. NGR-based probes show promise for future clinical tumor imaging applications.
Area of Science:
- Biomedical imaging
- Molecular biology
- Oncology
Background:
- Molecular imaging requires high signal/background ratios for effective visualization.
- The Asn-Gly-Arg (NGR) tripeptide specifically targets tumor vasculature.
- NGR binds to aminopeptidase N (APN or CD13) on tumor cells, enabling internalization.
Purpose of the Study:
- To review recent developments in NGR peptide-based tumor imaging.
- To highlight the potential of NGR probes in clinical applications.
Main Methods:
- Phage display was used to select the NGR tripeptide.
- NGR was conjugated with fluorescent or radiolabeled imaging probes.
- Tumor imaging studies utilizing NGR probes were reviewed.
Main Results:
- NGR peptide demonstrates specific targeting of tumor vasculature.
- Internalization into tumor cells via the endosomal pathway is facilitated by APN binding.
- Preliminary studies show potential for NGR probes in tumor imaging.
Conclusions:
- NGR peptide is a promising candidate for developing targeted tumor imaging agents.
- Further development of NGR-based probes could lead to future clinical applications in oncology.
