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Updated: May 17, 2026

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Published on: December 7, 2012

Component pathogen inactivation: a critical review.

¹Edinburgh University, Edinburgh, UK. olive.drummond@lineone.net

|November 9, 2012

Summary

This summary is machine-generated.

Pathogen inactivation (PI) technologies for plasma and platelets are effective against most pathogens, with minimal clinical impact. PI offers an attractive alternative to traditional blood safety measures, enhancing component safety.

Keywords:

clinical trial fresh-frozen plasma pathogen inactivation platelet components red cell components review

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Inactivation of Pathogens via Visible-Light Photolysis of Riboflavin-5′-Phosphate

Inactivation of Pathogens via Visible-Light Photolysis of Riboflavin-5′-Phosphate

Published on: April 6, 2022

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Last Updated: May 17, 2026

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Published on: December 7, 2012

Inactivation of Pathogens via Visible-Light Photolysis of Riboflavin-5′-Phosphate

Inactivation of Pathogens via Visible-Light Photolysis of Riboflavin-5′-Phosphate

Published on: April 6, 2022

Area of Science:

Blood Transfusion Safety
Microbiology
Immunology

Background:

Pathogen inactivation (PI) technologies are increasingly preferred for plasma and platelet products.
This review focuses on clinical evidence for licensed PI component technologies and developing red cell PI.

Purpose of the Study:

To summarize clinical evidence for licensed PI component technologies.
To review red cell PI technologies under development.

Main Methods:

Literature review of available data on licensed PI technologies.

Main Results:

PI technologies demonstrate good efficacy against most pathogens, with limitations for certain nonenveloped viruses.
Clinical trials and haemovigilance indicate minimal clinical significance of observed potency loss, with some exceptions.
No confirmed adverse toxicological effects or neoantigen formation with currently licensed PI products.

Conclusions:

Platelet PI is adopted to reduce bacterial contamination.
PI methods are attractive alternatives for pathogen testing, gamma-irradiation, and leucodepletion.
PI enhances the safety and attractiveness of blood components.