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Cutaneous reactions to proton pump inhibitors: a case-control study
Leena Chularojanamontri1, Sukhum Jiamton, Araya Manapajon
1Department of Dermatology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Journal of Drugs in Dermatology : JDD
|November 9, 2012
Summary
Proton pump inhibitor (PPI) use can cause skin reactions, including rashes. Patients with prior adverse drug reactions face a higher risk of developing these cutaneous side effects from PPIs.
Area of Science:
- Pharmacovigilance
- Dermatology
- Internal Medicine
Background:
- Limited studies exist on cutaneous adverse reactions to proton pump inhibitors (PPIs).
- Most available data comprises case reports, highlighting a need for broader investigation.
Purpose of the Study:
- To identify patterns of cutaneous reactions associated with PPI use.
- To assess the risk of developing PPI-induced drug eruptions in adult patients.
Main Methods:
- Review of spontaneous adverse event reports linked to PPIs from January 2005 to May 2010.
- Inclusion of 64 patients with PPI reaction history and 65 controls matched by hospital number.
Main Results:
- Prevalence of cutaneous reactions ranged from 3 to 20 per 100,000 treated individuals.
- Omeprazole was implicated in most reactions (78.1%), with maculopapular rash being the most common (43.8%).
- No cross-reactivity was observed between different PPIs.
Conclusions:
- Cutaneous adverse reactions to PPIs span from mild rashes to severe, life-threatening conditions.
- A history of adverse drug reactions increases the risk for developing PPI-related cutaneous reactions.
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