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Related Experiment Video

Updated: May 17, 2026

An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment
08:43

An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment

Published on: July 28, 2012

Telomerase activity in bladder cancer tissue.

Akihiro Morii1, Akira Komiya, Akiou Okumura

  • 1Department of Urology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama 930-0194, Japan.

Experimental and Therapeutic Medicine
|November 9, 2012
PubMed
Summary

Telomerase activity, an enzyme maintaining chromosome ends, was found in most bladder cancers. While linked to early-stage tumors, it may predict better outcomes in advanced, high-grade bladder cancers.

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Telomeres and Telomerase02:41

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Telomerase is an enzyme crucial for maintaining telomeres, the protective caps at the ends of chromosomes.
  • Aberrant telomerase activity is a hallmark of many human cancers, including bladder cancer.
  • Understanding telomerase's role in bladder cancer is vital for diagnosis and prognosis.

Purpose of the Study:

  • To evaluate telomerase activity in bladder cancer tissues.
  • To investigate the association between telomerase activity and bladder cancer characteristics.
  • To determine if telomerase activity correlates with patient prognosis.

Main Methods:

  • Telomeric Repeat Amplification Protocol (TRAP) assay was used to detect telomerase activity.
  • Bladder tissue specimens from 81 patients (75 with cancer, 6 controls) were analyzed.

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Evaluation of the Efficacy of the H. pylori Protein HP-NAP as a Therapeutic Tool for Treatment of Bladder Cancer in an Orthotopic Murine Model

Published on: May 29, 2015

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Last Updated: May 17, 2026

An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment
08:43

An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment

Published on: July 28, 2012

Evaluation of the Efficacy of the H. pylori Protein HP-NAP as a Therapeutic Tool for Treatment of Bladder Cancer in an Orthotopic Murine Model
06:12

Evaluation of the Efficacy of the H. pylori Protein HP-NAP as a Therapeutic Tool for Treatment of Bladder Cancer in an Orthotopic Murine Model

Published on: May 29, 2015

  • Correlation analysis was performed between telomerase activity and tumor grade, stage, and survival.

    • Main Results:

    • Telomerase activity was detected in 49 out of 75 (65.3%) bladder cancer patients.
    • Telomerase positivity was associated with lower grade and lower stage bladder cancer.
    • In patients with invasive and grade 3 tumors, telomerase positivity indicated an improved prognosis.

    Conclusions:

    • Telomerase is frequently active in bladder cancer, even in early stages.
    • Telomerase activity correlates with less aggressive tumor features.
    • Telomerase may serve as a prognostic marker for advanced-stage and high-grade bladder cancers.