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Bisphosphonates and their clinical implications in endodontic therapy
A-T Moinzadeh1, H Shemesh, N A M Neirynck
1Department of Endodontology, Academic Center of Dentistry Amsterdam, University of Amsterdam and VU University, The Netherlands. a.moinzadeh@acta.nl
International Endodontic Journal
|November 10, 2012
Summary
This review details factors contributing to bisphosphonate-related osteonecrosis of the jaw (BRONJ) in patients undergoing endodontic treatment. It offers prevention strategies to mitigate this risk.
Area of Science:
- Oral Surgery
- Pharmacology
- Dental Medicine
Background:
- Bisphosphonates (BPs) are widely used for bone diseases.
- Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious adverse effect.
- BRONJ is debilitating and challenging to treat, necessitating preventive measures.
Purpose of the Study:
- To review factors influencing BRONJ development in patients undergoing nonsurgical endodontic treatment.
- To provide recommendations for preventing BRONJ in at-risk patients.
- To discuss the clinical presentation, epidemiology, pathogenesis, and risk factors of BRONJ.
Main Methods:
- Literature review of bisphosphonate drugs and BRONJ.
- Analysis of risk factors associated with nonsurgical endodontic procedures.
- Synthesis of preventive strategies for BRONJ.
Main Results:
- Nonsurgical endodontic treatment, while generally safe, requires careful consideration in patients on bisphosphonates.
- Dental extraction is a primary trigger for BRONJ.
- Specific risk factors for BRONJ development post-endodontic treatment are identified.
Conclusions:
- Preventing BRONJ in patients on bisphosphonates undergoing endodontic treatment is crucial.
- Implementing proposed preventive strategies can reduce the incidence of BRONJ.
- Further research into risk mitigation for BRONJ is warranted.
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