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Updated: May 17, 2026
05:20
A Colorimetric Assay that Specifically Measures Granzyme B Proteolytic Activity: Hydrolysis of Boc-Ala-Ala-Asp-S-Bzl
Published on: November 28, 2014
Controversies in granzyme biology
O Susanto1, J A Trapani, D Brasacchio
1Cancer Cell Death Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Australia.
Tissue Antigens
|November 10, 2012
Summary
Granzymes (Grz) are serine proteases in cytotoxic lymphocytes. This review discusses their accepted and controversial cytotoxic and non-cytotoxic immune functions.
Area of Science:
- Immunology
- Molecular Biology
- Protease Function
Background:
- Granzymes (Grz) are serine proteases stored in cytotoxic lymphocyte granules.
- They play a crucial role in immune surveillance and function.
- Emerging evidence suggests diverse roles beyond cytotoxicity.
Purpose of the Study:
- To review the established and emerging functions of Granzymes.
- To discuss both the cytotoxic and non-cytotoxic roles of Granzymes.
- To highlight accepted and controversial aspects of Granzyme function.
Main Methods:
- Literature review of Granzyme research.
- Analysis of published studies on Granzyme functions.
- Synthesis of current knowledge on Granzyme activities.
Main Results:
- Granzymes exhibit potent cytotoxic activities.
- Non-cytotoxic functions of Granzymes are increasingly recognized.
- Several Granzyme functions remain under active investigation and debate.
Conclusions:
- Granzymes are critical immune mediators with multifaceted roles.
- Understanding both cytotoxic and non-cytotoxic functions is essential.
- Further research is needed to clarify controversial Granzyme activities.
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