Related Experiment Video
Updated: May 17, 2026

08:07
Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Published on: September 6, 2017
A novel HLA-A*66 allele, A*66:07
Tissue Antigens
|November 10, 2012
Summary
The newly identified HLA-A*66:07 allele is distinct from HLA-A*66:01 due to a single amino acid substitution at position 165. This finding contributes to the understanding of human leukocyte antigen diversity.
Area of Science:
- Immunogenetics
- Molecular Biology
- Human Leukocyte Antigen (HLA) system
Background:
- The Human Leukocyte Antigen (HLA) system is crucial for immune response and transplantation.
- Allelic variations within HLA genes contribute to immune diversity and disease susceptibility.
- Accurate HLA typing is essential for clinical applications.
Purpose of the Study:
- To characterize a novel HLA-A allele, designated HLA-A*66:07.
- To identify the specific genetic differences between HLA-A*66:07 and previously known alleles.
Main Methods:
- High-resolution HLA typing techniques were employed.
- Sequence analysis was performed to identify nucleotide and amino acid variations.
Main Results:
- The HLA-A*66:07 allele was identified and characterized.
- A single amino acid exchange at position 165 distinguishes HLA-A*66:07 from the HLA-A*66:01 allele.
Conclusions:
- HLA-A*66:07 represents a distinct allele within the HLA-A*66 family.
- This discovery expands the known repertoire of HLA-A alleles.
- Further studies may explore the functional implications of this amino acid substitution.
Related Concept Videos
Multiple Allele Traits
The Concept of Multiple Allelism
Lethal Alleles
Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Blood Types
Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
Genome-wide Association Studies-GWAS
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
Exon Recombination
The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes.
Exon shuffling follows “splice frame rules.” Each exon has three reading...
Exon shuffling follows “splice frame rules.” Each exon has three reading...
Single Nucleotide Polymorphisms-SNPs
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...

