Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current medication...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Acid Suppressive Drugs for Peptic Ulcer Disease: Proton Pump Inhibitors01:13

Acid Suppressive Drugs for Peptic Ulcer Disease: Proton Pump Inhibitors

Peptic ulcers, often induced by H. pylori infections or NSAID usage, arise from disruptions in the delicate balance of gastric acid production. Peptic ulcers stem from heightened gastric acid levels due to H. pylori infections or NSAID use. The protective mucus layer diminishes in the presence of these factors, allowing gastric acid to erode the stomach lining and form ulcers.
Gastric acid, a potent cocktail of hydrogen and chloride ions, is produced in specialized parietal cells within the...
Acid Suppressive Drugs for Peptic Ulcer Disease: Antacids01:31

Acid Suppressive Drugs for Peptic Ulcer Disease: Antacids

In the complex environment of the gastric lumen, excessive acid secretion can lead to the formation or worsening of ulcers within the delicate mucosal layer. Antacids, such as sodium bicarbonate and calcium carbonate, provide relief by neutralizing this acid, transforming it into harmless salt and water. This neutralization process raises the gastric pH from a highly acidic level of 1 to a more basic 3-4, reducing the acidity within the stomach.
However, this neutralization reaction between...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Joint analysis of longitudinal and recurrent event data: A functional regression approach with autoregressive frailty.

Statistical methods in medical research·2026
Same author

Bone Disease in Non-Cystic Fibrosis Bronchiectasis: Connections, Mechanisms, and Care Gaps.

Chest·2026
Same author

The Role of Altered Mineral Metabolism in Kidney Stone Disease: Is Vitamin D the Key?

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same author

Calcium Phosphate Nephrolithiasis: A Comprehensive Review.

Kidney medicine·2026
Same author

Prevention of urinary stones with hydration: a randomised clinical trial of an adherence intervention.

Lancet (London, England)·2026
Same author

Use and Implications of the Fracture Risk Assessment Tool in Primary Hyperparathyroidism.

JAMA network open·2026

Related Experiment Videos

Safety of bisphosphonates.

Catalina Orozco1, Naim M Maalouf

  • 1Rheumatology Associates, 8144 Walnut Hill Lane, Dallas, TX 75231, USA.

Rheumatic Diseases Clinics of North America
|November 10, 2012
PubMed
Summary

Bisphosphonates effectively reduce fracture risk in osteoporosis patients. However, long-term use may increase risks of rare side effects like atypical fractures and jaw osteonecrosis, necessitating careful monitoring.

Area of Science:

  • Pharmacology
  • Bone Metabolism
  • Clinical Therapeutics

Background:

  • Bisphosphonates are primary antiresorptive agents for osteoporosis.
  • Clinical trials confirm bisphosphonates significantly decrease osteoporotic fracture risk.
  • Long-term bisphosphonate use is associated with emerging safety concerns.

Purpose of the Study:

  • To review the major adverse effects of bisphosphonate therapy.
  • To identify patient populations at higher risk for these side effects.
  • To offer guidance on the safe and effective use of bisphosphonates.

Main Methods:

  • Literature review of clinical trials and post-marketing surveillance data.
  • Analysis of reported adverse events associated with bisphosphonate use.

Related Experiment Videos

  • Synthesis of current evidence on bisphosphonate safety and efficacy.

    • Main Results:

    • Bisphosphonates are proven effective in reducing osteoporotic fractures.
    • Rare but serious side effects include atypical femoral fractures and osteonecrosis of the jaw.
    • Potential associations with esophageal cancer and atrial fibrillation warrant further investigation.

    Conclusions:

    • Bisphosphonates offer significant benefits for osteoporosis management.
    • Awareness of rare adverse events is crucial for long-term patient safety.
    • Individualized risk-benefit assessment and monitoring are essential for optimal bisphosphonate therapy.