Perioperative drug safety in patients with rheumatoid arthritis

The expansion of therapeutic options for rheumatoid arthritis (RA) has improved the functional, quality of life, and radiographic outcomes for patients, although immunomodulatory and immunosuppressive effects may increase the potential for complications related to infection risk or wound healing after orthopedic surgery. Additionally, medications without significant effects on the immune system, such as nonsteroidal anti-inflammatory drugs, may have consequences in terms of bleeding or cardiovascular disease. Increased vigilance is required when using these medications, particularly in the perioperative period. This article considers the recent literature and data on the perioperative use of medications commonly used in RA.