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Related Experiment Video

Updated: May 17, 2026

Contrast Enhanced Vessel Imaging using MicroCT
05:50

Contrast Enhanced Vessel Imaging using MicroCT

Published on: January 27, 2011

Small animal imaging and examination by micro-CT.

Sergio X Vasquez1, Neha Shah, Alan M Hoberman

  • 1Numira Biosciences, Salt Lake City, UT, USA.

Methods in Molecular Biology (Clifton, N.J.)
|November 10, 2012
PubMed
Summary

Micro-computed tomography (micro-CT) offers non-destructive, whole-mount imaging of skeletal structures in preclinical models. This advanced technique provides detailed bone analysis, including bone mineral density, and supports digital archiving for research.

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Non-invasive Skeletal Muscle Quantification in Small Animals Using Micro-computed Tomography

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Area of Science:

  • Biomedical Imaging
  • Preclinical Research
  • Skeletal Biology

Background:

  • Micro-computed tomography (micro-CT) is a powerful imaging modality for preclinical skeletal research.
  • It enables non-destructive, whole-mount investigation of skeletal structures at various developmental stages.

Purpose of the Study:

  • To highlight the capabilities and applications of micro-CT in skeletal research.
  • To discuss the advantages and limitations of micro-CT for analyzing bone properties.

Main Methods:

  • Utilizes micro-CT scanners for high-resolution, non-destructive imaging of preclinical skeletal specimens.
  • Performs both qualitative and quantitative analyses, including bone mineral density (BMD) and hydroxyapatite content.
  • Offers in vivo and ex vivo scanning options with volumetric or slice-thru data presentation.

Main Results:

  • Micro-CT provides detailed qualitative imaging of skeletal morphology.
  • Quantitative metrics such as BMD, cortical and trabecular bone analysis, and mgHA/cc are achievable.
  • Digitally archivable data and flexible data presentation formats are key benefits.

Conclusions:

  • Micro-CT is a versatile tool for comprehensive skeletal analysis in preclinical research.
  • Its non-destructive nature and quantitative capabilities make it invaluable for studying bone development and disease.
  • Ongoing research aims to expand micro-CT applications to soft tissue imaging.