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Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres
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An overview of preparation and evaluation sustained-release injectable microspheres
Liandong Hu1, Hailei Zhang, Weihua Song
1College of Pharmaceutical Sciences, Hebei University, No. 180 Wusi Road, Baoding 071002, P.R. China. hbupharm@126.com
Journal of Microencapsulation
|November 13, 2012
Summary
Sustained-release injectable microspheres offer advantages over traditional drugs. This review covers polymer selection, preparation, sterilization, and release behavior analysis for market launch.
Area of Science:
- Pharmaceutical Sciences
- Biomaterials Engineering
Background:
- Sustained-release injectable microspheres represent a novel parenteral administration system with significant advantages over traditional dosage forms.
- These benefits include reduced administration frequency, fewer adverse side effects, and elimination of surgical procedures, driving progress in their development.
Purpose of the Study:
- This review aims to provide guidance for the market launch of novel sustained-release injectable microspheres.
- It addresses key aspects of their development, from material selection to release behavior characterization.
Main Methods:
- The review summarizes commonly used biodegradable polymers for microsphere formulation.
- It details various preparation and sterilization methods relevant to these systems.
- Methods for analyzing in vitro and in vivo release behaviors and their correlations are also discussed.
Main Results:
- The review consolidates information on essential components and processes for developing sustained-release microspheres.
- It highlights the importance of understanding and predicting drug release profiles.
- Strategies for establishing in vitro-in vivo correlations (IVIVC) are presented.
Conclusions:
- This review provides a comprehensive overview of sustained-release injectable microspheres, focusing on practical aspects for development and market entry.
- It emphasizes the need for robust characterization and correlation studies to ensure successful product launch.
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