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Quality control data for low blood lead concentrations by three methods used in clinical studies
J D Osterloh1, D S Sharp, B Hata
1Department of Medicine, University of California, San Francisco.
Abstract:
During several clinical studies of blood lead (BPb) concentrations from environmental exposure, quality control data for three different methods of BPb analysis were compiled. Anodic stripping voltammetry by a commercial method (cASV), a modified method (mASV), and graphite furnace atomic absorption spectrophotometry (GFAA) were compared for precision at low BPb concentrations (less than 25 micrograms/dL) analyses. Both duplicate and interassay precision, as well as direct determinations of intraassay precision, were less for GFAA. The mASV incorporated calibration with lower BPb standards than used in the commercial protocol. This appeared to correct nonlinearity in response at lower BPb and reduced the bias between ASV and GFAA at BPb concentrations typical of environmental exposure levels.