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Updated: May 17, 2026

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)
Published on: June 20, 2014
Synthesis of C3-arylated-3-deazauridine derivatives with potent anti-HSV-1 activities
Julien Lalut1, Ludovic Tripoteau, Christel Marty
1Université Bordeaux 1, UMR CNRS 5255, Institut des Sciences Moléculaires, 351 Cours de la Libération, 33405 Talence Cedex, France.
Abstract:
A series of 3-deazauridines (3-DU) analogues were synthesized and evaluated in vitro for their antiherpetic activity against HSV-1 on Vero cell lines by cell viability. A first campaign of tests suggested that C3-arylated-3-DU derivatives could constitute a novel family of antiherpetic agents. A second campaign of biological evaluations led to the discovery of two potent anti-HSV-1 agents with comparable activity than acyclovir.
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