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Related Concept Videos

Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
Bacterial Signaling01:30

Bacterial Signaling

Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the ATP-dependent...
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...

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Related Experiment Video

Updated: May 17, 2026

Synthesis and Assay of Vibrio Quorum Sensing Inhibitors
03:29

Synthesis and Assay of Vibrio Quorum Sensing Inhibitors

Published on: May 31, 2024

Quorum sensing inhibitors: an overview.

Vipin Chandra Kalia1

  • 1Microbial Biotechnology and Genomics, CSIR-Institute of Genomics and Integrative Biology (IGIB), Delhi University Campus, Mall Road, Delhi-110007, India. vckalia@igib.res.in

Biotechnology Advances
|November 13, 2012
PubMed
Summary

Antibiotic resistance is a growing problem. This review explores natural and synthetic quorum sensing inhibitors (QSIs) that can disrupt bacterial biofilms, offering new treatment strategies.

Area of Science:

  • Microbiology
  • Pharmacology
  • Biochemistry

Background:

  • Antibiotic resistance is a significant global health threat, driven by the overuse of antibiotics.
  • Bacterial infections often involve biofilms, which are protected communities of bacteria regulated by quorum sensing (QS).
  • Disrupting QS is a promising strategy to combat bacterial infections and overcome resistance.

Purpose of the Study:

  • To review natural and synthetic quorum sensing inhibitors (QSIs) for their potential in treating bacterial infections.
  • To highlight molecules that quench quorum sensing (QQ) pathways.
  • To explore the therapeutic potential of QSIs derived from safe prokaryotes, legumes, and medicinal plants.

Main Methods:

  • Literature review of natural and synthetic compounds with quorum quenching (QQ) activity.

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Quantification of Violacein in Chromobacterium violaceum and Its Inhibition by Bioactive Compounds
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Quantification of Violacein in Chromobacterium violaceum and Its Inhibition by Bioactive Compounds

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Last Updated: May 17, 2026

Synthesis and Assay of Vibrio Quorum Sensing Inhibitors
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Published on: May 31, 2024

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases
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Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases

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Quantification of Violacein in Chromobacterium violaceum and Its Inhibition by Bioactive Compounds
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Published on: August 8, 2025

  • Analysis of molecules that interfere with bacterial quorum sensing (QS) systems.
  • Identification of potential sources for QSIs, including prokaryotes, eukaryotes, legumes, and medicinal plants.

    • Main Results:

    • Bioactive molecules from prokaryotes and eukaryotes can quench QS, inhibiting bacterial communication and biofilm formation.
    • Both natural products and synthetic compounds demonstrate effectiveness in QQ.
    • Safe prokaryotes, legumes, and medicinal plants are identified as promising sources of QSIs.

    Conclusions:

    • Quorum sensing inhibitors (QSIs) offer a viable alternative or adjunct to traditional antibiotics.
    • Targeting QS pathways can reduce bacterial virulence and overcome multiple drug resistance.
    • Further research into natural and synthetic QSIs may lead to more effective treatments with lower drug dosages.