Related Experiment Video

Updated: May 17, 2026

Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy
09:57

Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy

Published on: September 20, 2024

Predictors of Epilepsy in Children With Cerebrovascular Disease

Norma M M Morais1, Josiane Ranzan, Rudimar S Riesgo

  • 11Postgraduate Program in Child and Adolescent Health, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.

Journal of Child Neurology
|November 13, 2012
PubMed

Insights

Pediatric post-stroke epilepsy is common, affecting nearly 30% of children. Late-onset seizures and cortical involvement significantly increase epilepsy risk following stroke in children.

Area of Science:

  • Neurology
  • Pediatric Neurology
  • Epileptology

Background:

  • Post-stroke seizures and epilepsy are recognized complications in children.
  • These conditions remain understudied in pediatric populations, necessitating further research into risk factors and prevalence.

Purpose of the Study:

  • To assess the risk of post-stroke seizures in children.
  • To determine the prevalence of post-stroke epilepsy in pediatric patients.
  • To identify risk factors associated with epilepsy development after stroke in children.

Main Methods:

  • Retrospective cohort study analyzing medical records of 65 children (aged 0-18 years).
  • Evaluation of seizure occurrence (early vs. late-onset) and epilepsy development.
  • Statistical analysis including Poisson regression to calculate relative risks.

Main Results:

  • Epileptic seizures occurred in 64.6% of children post-stroke, with most within 24 hours.
  • Post-stroke epilepsy developed in 29.2% of children.
  • Late-onset seizures (P=.034) and cortical involvement (P=.01) were significantly associated with epilepsy.
  • Relative risk of epilepsy was 2.4 for late-onset seizures and 3.7 for cortical involvement.

Conclusions:

  • Post-stroke epilepsy is a significant concern in children.
  • Late-onset seizures and cortical involvement are key risk factors for developing epilepsy after stroke in pediatric patients.
  • Further research and clinical attention are warranted for this vulnerable population.

Keywords:
cerebrovascular diseaseepilepsyseizurestroke

More Related Videos

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy10:22

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy

Published on: December 6, 2016

Sampling Cerebrospinal Fluid and Blood from Lateral Tail Vein in Rats During EEG Recordings10:46

Sampling Cerebrospinal Fluid and Blood from Lateral Tail Vein in Rats During EEG Recordings

Published on: September 1, 2023

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Epilepsy ll: Types01:22

Epilepsy ll: Types

Recurrent seizures, stemming from abnormal electrical activity in the brain, are the defining characteristic of epilepsy, a chronic neurological condition. Because seizure features vary greatly, epilepsy is classified using two systems: by seizure type and by epilepsy syndromes. These classifications enable clinicians to describe seizure patterns and select suitable treatment strategies.I. Classification by Seizure Type1. Focal EpilepsyFocal epilepsy begins in one hemisphere of the brain.
Seizures: Classification01:13

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
Seizures l: Introduction01:20

Seizures l: Introduction

Understanding seizures and epilepsy relies on key definitions that help in recognizing, classifying, and managing these disorders. These definitions provide a framework for recognizing, classifying, and managing seizure disorders.DefinitionsA seizure is a sudden, abnormal burst of electrical activity in the brain that can cause changes in awareness, movement, sensation, or behavior, depending on the area involved. Epilepsy is a chronic condition characterized by recurrent, unprovoked seizures,...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...