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Updated: May 17, 2026

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A Method to Study α-Synuclein Toxicity and Aggregation Using a Humanized Yeast Model
Published on: November 25, 2022
O-GlcNAc modification prevents peptide-dependent acceleration of α-synuclein aggregation
Nicholas P Marotta1, Carli A Cherwien, Tharindumala Abeywardana
1Department of Chemistry, University of Southern California, Los Angeles, CA 90089-0744, USA.
Chembiochem : a European Journal of Chemical Biology
|November 13, 2012
Abstract:
Sweet relief: the Parkinson's disease- associated protein α-synuclein is post-translationally modified by N-acetylglucosamine (O-GlcNAc), but the biochemical consequences are unknown. Here we show that an O-GlcNAc-modified peptide does not participate in α-synuclein aggregation, thus suggesting that O-GlcNAc might directly inhibit aggregation in cells.

