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Published on: July 3, 2018
Three dimensional, sheathless, and high-throughput microparticle inertial focusing through geometry-induced secondary
Aram J Chung1, Daniel R Gossett, Dino Di Carlo
1Department of Bioengineering, California NanoSystems Institute, University of California, Los Angeles, CA 90095, USA.
Abstract:
A novel inertial focusing platform creates a single-stream microparticle train in a single-focal plane without sheath fluids and external forces, all in a high-throughput manner. The proposed design consists of a low-aspect-ratio straight channel interspersed with a series of constrictions in height arranged orthogonally, making use of inertial focusing and geometry-induced secondary flows. Focusing efficiency as high as 99.77% is demonstrated with throughput as high as 36 000 particles s(-1) for a variety of different sized particles and cells.
