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Notch-mediated suppression of TSC2 expression regulates cell differentiation in the Drosophila intestinal stem cell

Subir Kapuria1, Jason Karpac, Benoit Biteau

  • 1Department of Biology, University of Rochester, Rochester, New York, United States of America.

Plos Genetics
|November 13, 2012
PubMed

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

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