Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Radiographic sacroiliitis progression in psoriatic arthritis.

Rheumatology (Oxford, England)·2026
Same author

Do Patients Diagnosed with Psoriatic Arthritis Before or Concurrently with Psoriasis Have Different Disease Phenotype and Outcomes?

The Journal of rheumatology·2026
Same author

Understanding the transition from psoriasis to psoriatic arthritis: the role of targeted therapy.

EULAR rheumatology open·2026
Same author

Body mass index and achievement of minimal disease activity in psoriatic arthritis across different classes of advanced therapy.

Rheumatology (Oxford, England)·2026
Same author

Variable Selection for Illness-Death Processes Under Dual Observation Schemes.

Statistics in medicine·2026
Same author

Two-phase designs for biomarker studies when disease processes are under intermittent observation.

Biometrics·2026

Related Experiment Video

Updated: May 16, 2026

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination
10:32

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination

Published on: August 24, 2015

Clinical trials evaluating pathogen-reduced platelet products: methodologic issues and recommendations.

Richard J Cook1, Nancy M Heddle

  • 1Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada. rjcook@uwaterloo.ca

Transfusion
|November 14, 2012
PubMed
Summary

This review discusses challenges in platelet (PLT) transfusion trials evaluating pathogen reduction technology. Harmonizing trial designs and analyses is recommended for future studies on pathogen-reduced PLT products.

More Related Videos

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
10:25

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

Published on: March 19, 2016

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
12:40

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Published on: December 7, 2012

Related Experiment Videos

Last Updated: May 16, 2026

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination
10:32

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination

Published on: August 24, 2015

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
10:25

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

Published on: March 19, 2016

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
12:40

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Published on: December 7, 2012

Area of Science:

  • Hematology
  • Transfusion Medicine
  • Clinical Trials Methodology

Background:

  • Numerous randomized trials of platelet (PLT) products exist with varied designs, endpoints, and analyses.
  • Pathogen reduction technology (PRT) is increasingly used in PLT products, necessitating standardized evaluation methods.

Purpose of the Study:

  • To discuss methodologic issues in the design and analysis of PLT transfusion trials evaluating PRT.
  • To provide recommendations for conducting future PLT transfusion trials using PRT.

Main Methods:

  • Review of six randomized clinical trials of pathogen-inactivated PLT products.
  • Discussion of associated methodologic issues encountered in these trials.

Main Results:

  • Significant variation exists in trial designs, outcomes, and analytical methods across studies.
  • The need for harmonization in conducting trials of pathogen-reduced PLT products is evident to facilitate comparisons and synthesis of results.

Conclusions:

  • Future randomized trials of pathogen-reduced PLT products require clearly stated hypotheses and research questions.
  • Optimal trial design, relevant outcomes, defined observation periods, and robust statistical analyses are crucial for valid hypothesis testing and treatment effect estimation.