Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Neural Regulation

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

Alzheimer Disease ll: Pathophysiology

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...

Alzheimer's Disease: Overview

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...

Alzheimer Disease l: Introduction

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A prospective study on the efficacy of oral estrogen in female patients with acromegaly.

Pituitary·2022

Same author

Congenital Zika syndrome is associated with maternal protein malnutrition.

Science advances·2020

Same author

Congenital Zika virus infection: a neuropathological review.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2017

Same author

A Family with Friedreich Ataxia and Onion-Bulb Formations at Sural Nerve Biopsy.

Annals of the New York Academy of Sciences·2017

Same author

Microglia-glioblastoma interactions: New role for Wnt signaling.

Biochimica et biophysica acta. Reviews on cancer·2017

Same author

Rescuing axons from degeneration does not affect retinal ganglion cell death.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2016

Search research articles

Related Experiment Video

Updated: May 16, 2026

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis

Published on: July 16, 2021

Neuroproteomics: an insight into ALS.

D M F Mendonça¹, L Pizzati, K Mostacada

¹Departamento de Biociências, Universidade Federal de Sergipe, Sergipe, Brazil. deise_mendonca@ufs.br

Neurological Research

|November 14, 2012

Summary

This summary is machine-generated.

Researchers identified novel protein biomarkers in cerebrospinal fluid (CSF) for amyotrophic lateral sclerosis (ALS). Proteins involved in iron, zinc binding, and the ubiquitin-proteasome pathway were found in ALS patients, offering new diagnostic possibilities.

More Related Videos

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies

Published on: July 29, 2007

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae

Published on: February 25, 2022

Related Experiment Videos

Last Updated: May 16, 2026

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis

Published on: July 16, 2021

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies

Published on: July 29, 2007

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae

Published on: February 25, 2022

Area of Science:

Neuroscience
Biochemistry
Proteomics

Background:

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with unknown causes.
Current ALS diagnosis relies on clinical examination and exclusion of other conditions, lacking definitive biomarkers.
The ubiquitin-proteasome system and metal ion homeostasis are implicated in ALS pathogenesis.

Purpose of the Study:

To identify differentially expressed proteins in cerebrospinal fluid (CSF) of ALS patients compared to controls.
To discover a panel of potential protein biomarkers for ALS diagnosis.
To investigate the role of identified proteins in ALS pathophysiology.

Main Methods:

Proteomic analysis of CSF samples from ALS patients and healthy controls.
Two-dimensional (2D) electrophoresis to separate proteins.
Matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry for protein identification.

Main Results:

Several differentially expressed proteins were identified in ALS CSF.
Proteins including parkin-like and various iron and zinc binding proteins were found at altered levels.
These findings suggest potential links between protein dysregulation, metal ion metabolism, and the ubiquitin-proteasome system in ALS.

Conclusions:

The identified proteins represent potential biomarkers for ALS diagnosis.
Findings contribute to understanding the molecular mechanisms underlying ALS.
Further research into these proteins may advance ALS diagnostics and therapeutics.