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Connectivity-based parcellation of the human posteromedial cortex
Yaqin Zhang1, Lingzhong Fan, Yu Zhang
1Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 625014, China.
Researchers have identified 5 distinct subregions within the human posteromedial cortex (PMC), revealing specific functional roles for each part. This new parcellation scheme enhances our understanding of the brain
Area of Science:
- Neuroscience
- Brain Anatomy
- Functional Neuroimaging
Background:
- Regional variations in the posteromedial cortex (PMC) suggest subdivisions.
- A consensus on human PMC subdivision is currently lacking.
Purpose of the Study:
- To investigate the anatomical parcellation and connectivity patterns of human PMC subdivisions.
- To propose a refined parcellation scheme for the human PMC.
Main Methods:
- Diffusion tensor imaging (DTI) data from two independent volunteer groups.
- Anatomical and functional connectivity analyses.
- Comparison with macaque PMC data.
Main Results:
- Consistent parcellation of the human PMC into 5 subregions across datasets.
- Dorsal PMC subdivisions linked to sensorimotor, associative, and visual functions.
- Ventral PMC identified as a transitional region and core of the default mode network.
- Functional connectivity patterns mirrored anatomical connectivity for each subregion.
Conclusions:
- The proposed 5-subregion parcellation scheme for the human PMC is anatomically supported.
- Each subregion exhibits distinct functional and anatomical connectivity profiles.
- This refined parcellation facilitates subtler studies of PMC function and its role in brain networks.
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