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Updated: May 16, 2026

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
Published on: June 15, 2016
Non-coding transcription SETs up regulation
Swaminathan Venkatesh1, Jerry L Workman
1Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, MO 64110, USA.
Abstract:
An abundance of long non-coding RNA (lncRNA) present in most species from yeast to human are involved in transcriptional regulation, dosage compensation and imprinting. This underscores the importance of lncRNA as functional RNA despite the fact that they do not produce proteins. Two recent papers in Cell have demonstrated that transcription of the non-conserved lncRNAs, but not the RNAs themselves, is necessary to introduce co-transcriptional regulatory histone marks to regulate gene expression.
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