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Cis-regulatory Sequences

Cis-regulatory Sequences

Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...

Cis-regulatory Sequences

Cis-regulatory Sequences

Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...

Regulation of Expression Occurs at Multiple Steps

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...

Regulation of Expression Occurs at Multiple Steps

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...

Co-activators and Co-repressors

Co-activators and Co-repressors

Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...

Co-activators and Co-repressors

Co-activators and Co-repressors

Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...

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Related Experiment Video

Updated: May 16, 2026

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

Non-coding transcription SETs up regulation.

Swaminathan Venkatesh¹, Jerry L Workman

¹Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, MO 64110, USA.

|November 14, 2012

Summary

This summary is machine-generated.

Transcription of non-conserved long non-coding RNAs (lncRNAs), not the RNAs themselves, is essential for regulating gene expression through histone marks. This finding highlights the regulatory role of lncRNA transcription in gene regulation.

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Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

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Last Updated: May 16, 2026

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation

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Published on: March 7, 2018

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

Area of Science:

Molecular Biology
Genetics
Epigenetics

Background:

Long non-coding RNAs (lncRNAs) are crucial functional RNAs involved in various cellular processes, including transcriptional regulation.
Despite lacking protein-coding potential, lncRNAs play significant roles across species from yeast to humans.
Their involvement spans critical functions like dosage compensation and genomic imprinting.

Purpose of the Study:

To investigate the functional role of non-conserved long non-coding RNAs (lncRNAs) in gene expression regulation.
To determine whether the transcription of lncRNAs or the lncRNAs themselves are critical for epigenetic modifications.
To elucidate the mechanism by which lncRNAs influence gene expression through co-transcriptional processes.

Main Methods:

Analysis of two recent studies published in Cell.
Focus on the necessity of transcription versus the RNA molecule itself for regulatory functions.
Examination of co-transcriptional regulatory histone mark introduction.

Main Results:

The transcription of non-conserved lncRNAs is necessary for gene expression regulation.
The lncRNA molecules themselves are not the primary drivers of this regulation.
Transcription facilitates the introduction of specific co-transcriptional regulatory histone marks.

Conclusions:

lncRNA transcription, rather than the RNA molecule, is the key functional component for epigenetic regulation.
This mechanism involves the deposition of co-transcriptional regulatory histone marks.
The findings provide new insights into the regulatory roles of lncRNAs in gene expression.