Accelerated spike resampling for accurate multiple testing controls
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Updated: May 16, 2026

Introductory Analysis and Validation of CUT&RUN Sequencing Data
Published on: December 13, 2024
1Division of Applied Mathematics, Brown University, Providence, RI 02912, USA. Matthew_Harrison@brown.edu
Abstract:
Controlling for multiple hypothesis tests using standard spike resampling techniques often requires prohibitive amounts of computation. Importance sampling techniques can be used to accelerate the computation. The general theory is presented, along with specific examples for testing differences across conditions using permutation tests and for testing pairwise synchrony and precise lagged-correlation between many simultaneously recorded spike trains using interval jitter.
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