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[Mononuclear cell activation in status asthmaticus].

L Nagy1, C Corrigan, B Kay

  • 1Semmelweis Orvostudományi Egyetem Pulmonológiai Klinika, Budapest.

Orvosi Hetilap
|March 18, 1990
PubMed
Summary

In status asthmaticus, circulating mononuclear cells show increased activity and secrete more chemotactic cytokines. Steroid therapy reduced neutrophil chemotactic activity, suggesting a role for these cells in asthma inflammation.

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Area of Science:

  • Immunology
  • Pulmonology

Context:

  • Status asthmaticus is characterized by airway inflammation.
  • Circulating mononuclear cells (MNCs) play a role in inflammatory conditions.

Purpose:

  • To investigate the activity of MNCs and their secreted cytokines in patients with status asthmaticus.
  • To assess the impact of therapy on MNC activity and cytokine secretion.

Summary:

  • Patients with status asthmaticus exhibited increased MNC activity and spontaneous secretion of chemotactic cytokines.
  • Neutrophil chemotactic activity did not increase further after 24 hours but decreased after one week of steroid therapy.
  • Eosinophil chemotactic activity was undetectable in MNC supernatants from patients with acute severe asthma.

Impact:

  • MNC-derived cytokines may contribute to the pathogenesis of asthmatic bronchial inflammation.
  • MNC activation is a significant feature of status asthmaticus, offering potential therapeutic targets.

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