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[Preventive value of vitamin D in various doses based on a prospective study of healthy infants]
Insights
A higher vitamin D dose (1200 IU/day) in infants significantly reduced rickets symptoms compared to a lower dose (500 IU/day). This highlights the importance of adequate vitamin D for infant bone health and development.
Area of Science:
- Pediatrics
- Nutritional Science
- Public Health
Context:
- Healthy full-term infants from birth to one year of age were studied.
- Two groups received differing daily vitamin D doses: 500 IU/day and 1200 IU/day.
- Infants were from good social conditions and undisturbed pregnancies.
Purpose:
- To evaluate the efficacy of different vitamin D doses in rickets prophylaxis.
- To compare the incidence and severity of rickets between the two dosage groups.
- To identify optimal vitamin D supplementation levels for preventing rickets in infants.
Summary:
- 100 infants were assessed, with half showing rickets symptoms by 3 months, regardless of dose.
- The group receiving 500 IU/day vitamin D had significantly more clinical rickets evidence.
- Significant differences at one year included anterior fontanelle size, head circumference, dentition, and motor development.
Impact:
- Findings suggest 500 IU/day may be insufficient for rickets prevention in some infants.
- Higher vitamin D supplementation (1200 IU/day) demonstrates improved outcomes in bone development markers.
- This research informs public health recommendations for infant vitamin D supplementation to prevent rickets.
Abstract:
Authors have kept under review two groups of healthy full-term infants born from undisturbed pregnancy, who lived in good social conditions from birth to one year of age. One of the groups was given 500IU/die and the other 1200 IU/die vitamin D. Authors evaluated the effect of the different doses of vitamin D on the prophylaxis of the rickets. 100 infants were reviewed in both groups. The clinical, laboratory and radiological examination revealed symptoms referring to rickets at the half of infants in both groups as early as 3 month of age. In the group of infants having been given low prophylactic dose of vitamin D there was significantly larger number of patients showing clinical evidence for rickets in both ages. Also significant differences were found at the age of one year in the size of the anterior fontanelles and the head circumferences, the developing of dentition and walk and the disturbed rank of eruption of teeth.