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Updated: May 16, 2026

Localization, Identification, and Excision of Murine Adipose Depots
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Localization, Identification, and Excision of Murine Adipose Depots

Published on: December 4, 2014

Visceral adipose tissue quantification using Lunar Prodigy.

David L Ergun1, Megan P Rothney, Mary K Oates

  • 1GE Healthcare, Madison, WI, USA. ergundavid@gmail.com

Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry
|November 15, 2012
PubMed
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A new dual-energy X-ray absorptiometry (DXA) application, CoreScan, shows similar visceral adipose tissue (VAT) measurements between GE Prodigy and iDXA densitometers. However, the Prodigy exhibits lower precision, potentially requiring larger VAT changes for detection.

Area of Science:

  • Medical Imaging
  • Body Composition Analysis
  • Radiology

Background:

  • Dual-energy X-ray absorptiometry (DXA) is increasingly used for body composition analysis.
  • A novel DXA application, CoreScan, enables visceral adipose tissue (VAT) measurement in the android region.
  • Previous validation of CoreScan was performed on the Lunar iDXA densitometer.

Purpose of the Study:

  • To evaluate the agreement of CoreScan VAT measurements between GE Prodigy and Lunar iDXA densitometers.
  • To characterize differences in VAT measurement precision between the Prodigy and iDXA instruments.

Main Methods:

  • Paired DXA measurements using both Prodigy and iDXA densitometers were obtained from volunteers.
  • Empirical adjustments to VAT algorithm parameters were defined using a subset of data (n=59).

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  • Performance validation was conducted on a separate dataset (n=62).

    • Main Results:

    • Prodigy and iDXA CoreScan VAT measurements demonstrated high correlation (r=0.984).
    • The mean difference in VAT volume was -13.8 cm³ (95% CI: -45 to +17 cm³).
    • Short-term precision analysis revealed smaller measurement error variance for iDXA (7.3%) compared to Prodigy (9.8%).

    Conclusions:

    • CoreScan VAT measurements are comparable between GE Prodigy and Lunar iDXA densitometers.
    • The GE Prodigy densitometer exhibits lower VAT measurement precision than the Lunar iDXA.
    • Investigators using the Prodigy may need to target larger changes in VAT for reliable detection.