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Related Concept Videos

Decreased Body Temperature01:29

Decreased Body Temperature

A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by sustained extreme cold exposure, and severe...
Burn Injuries01:22

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Methods of reducing fever01:22

Methods of reducing fever

The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
Factors Affecting Body Temperature01:28

Factors Affecting Body Temperature

As a nurse, it is vital to understand the factors affecting body temperature to monitor variations and effectively evaluate deviations from regular.
Factors may  include:
Thermoregulation01:26

Thermoregulation

The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
Increased Body Temperature01:25

Increased Body Temperature

A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.

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Related Experiment Video

Updated: May 16, 2026

A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds
02:49

A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds

Published on: February 23, 2024

Moderate systemic hypothermia decreases burn depth progression.

Julie A Rizzo1, Pamela Burgess, Richard J Cartie

  • 1Dwight David Eisenhower Army Medical Center, Ft. Gordon, GA 30905, USA. julie.rizzo@us.army.mil

Burns : Journal of the International Society for Burn Injuries
|November 15, 2012
PubMed
Summary

Moderate hypothermia significantly reduced burn depth progression in rats. This therapeutic approach, particularly when applied immediately, demonstrated sustained protective effects and modulated gene expression, suggesting a novel treatment strategy for burns.

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Area of Science:

  • Biomedical research
  • Wound healing
  • Therapeutic hypothermia

Background:

  • Therapeutic hypothermia is recognized for its benefits in various human pathologies, including cardiac arrest, stroke, and traumatic injuries.
  • Burn depth progression is influenced by inflammation, a process known to be mitigated by hypothermia.
  • This study investigates the potential of moderate hypothermia to reduce burn depth progression.

Purpose of the Study:

  • To evaluate the efficacy of moderate hypothermia in decreasing burn depth progression.
  • To assess the impact of immediate versus delayed hypothermia application on burn severity.
  • To explore the molecular mechanisms underlying hypothermia's effects on burned skin through gene expression analysis.

Main Methods:

  • A second-degree thermal injury model (15% total body surface area) was established in rats.
  • Moderate hypothermia (31-33°C) was administered either immediately post-burn or with a 2-hour delay.
  • Burn depth was histologically assessed, and global gene expression in burned skin was analyzed.

Main Results:

  • Immediate hypothermia significantly decreased burn depth progression at 6 and 24 hours post-injury (18% reduction).
  • Delayed hypothermia showed a significant protective effect at 24 hours (23% reduction) but not at 6 hours.
  • Immediate hypothermia led to increased expression of protective genes (e.g., CCL4, CCL6, CXCL13) and decreased expression of matrix metalloproteinase-9.

Conclusions:

  • Systemic hypothermia effectively reduces burn depth progression in a rodent model.
  • The beneficial effects of hypothermia may be attributed to the up-regulation of protective genes and down-regulation of detrimental tissue remodeling genes.
  • Immediate application of moderate hypothermia appears most effective in mitigating burn depth progression.