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Phenotyping of mouse models with OCT.

M Dominik Fischer1, Ahmad Zhour, Christoph J Kernstock

  • 1Centre for Ophthalmology, University Eye Hospital, University of Tuebingen, Tuebingen, Germany. dominik.fischer@med.uni-tuebingen.de

Methods in Molecular Biology (Clifton, N.J.)
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Optical coherence tomography (OCT) enables noninvasive retinal imaging in mice, providing cross-sections comparable to histology. This technique allows for longitudinal studies, reducing animal numbers by enabling repeated measurements over time.

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Animal Research Models

Background:

  • Noninvasive retinal imaging is crucial for studying ocular diseases in animal models.
  • Optical coherence tomography (OCT) offers high-resolution cross-sectional imaging.
  • Histomorphometric analysis requires invasive procedures and larger animal cohorts.

Purpose of the Study:

  • To highlight the utility of OCT for noninvasive retinal imaging in mouse models.
  • To demonstrate the correlation between OCT data and histomorphometry.
  • To emphasize the benefits of OCT for longitudinal studies and animal reduction.

Main Methods:

  • Utilized Optical Coherence Tomography (OCT) for in vivo retinal imaging in mice.
  • Acquired virtual cross-sectional images of the retina.
  • Performed iterative measurements for time-line analyses.

Main Results:

  • OCT provided noninvasive, high-resolution retinal cross-sections in mice.
  • OCT data showed strong correlation with traditional histomorphometric data.
  • Iterative OCT measurements facilitated detection of dynamic retinal changes.

Conclusions:

  • OCT is a valuable, noninvasive tool for retinal imaging in mouse models.
  • OCT supports longitudinal studies, reducing the number of animals required.
  • This technique enhances the efficiency and ethical considerations of preclinical eye research.