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Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...

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Microfabrication of Implantable Optics Integrated in a Microstructured Imaging Window for Advanced In Vivo Imaging
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Implantable, multifunctional, bioresorbable optics.

Hu Tao1, Jana M Kainerstorfer, Sean M Siebert

  • 1Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.

Proceedings of the National Academy of Sciences of the United States of America
|November 15, 2012
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel implantable device using silk proteins for enhanced cancer imaging and targeted drug delivery. This biocompatible, resorbable technology offers real-time treatment feedback and promotes tissue regeneration.

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Area of Science:

  • Biomaterials Science
  • Biomedical Engineering
  • Personalized Medicine

Background:

  • Personalized medicine relies on advanced biomedical devices.
  • Current devices often lack integrated imaging and therapeutic feedback capabilities.
  • Silk proteins offer unique properties for biomaterial development.

Purpose of the Study:

  • To develop an implantable, biocompatible, and resorbable device integrating enhanced imaging, therapeutics, and feedback.
  • To leverage silk proteins' properties for a multifunctional biomedical device.
  • To demonstrate the device's efficacy in vitro and in vivo.

Main Methods:

  • Utilizing silk proteins as a biomaterial matrix for housing therapeutic components.
  • Incorporating microstructured optical elements for enhanced imaging.
  • Integrating drug delivery systems with real-time feedback mechanisms.
  • Evaluating device performance and biocompatibility in vitro and in vivo.

Main Results:

  • Demonstrated a novel silk-based device capable of simultaneous drug delivery and feedback.
  • Achieved enhanced imaging of malignancies and treatment monitoring.
  • Confirmed no adverse biological effects.
  • Observed slow degradation of the device, facilitating native tissue regeneration.

Conclusions:

  • Silk-based biomaterials can be engineered into multifunctional devices for personalized medicine.
  • The developed device offers integrated imaging, therapy, and feedback with biocompatibility and resorbability.
  • This technology holds promise for improved cancer diagnostics and therapeutics.