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Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold
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Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Published on: October 23, 2015

Injectable preformed scaffolds with shape-memory properties.

Sidi A Bencherif1, R Warren Sands, Deen Bhatta

  • 1School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

Proceedings of the National Academy of Sciences of the United States of America
|November 15, 2012
PubMed
Summary
This summary is machine-generated.

Injectable macroporous scaffolds made from natural polymers offer a minimally invasive delivery method. These shape-memory cryogels can be injected and rapidly recover their structure, showing promise for cell therapies.

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Polymer Chemistry

Background:

  • Minimally invasive delivery of biomaterials is crucial for reducing surgical risks.
  • Conventional surgical implantation of scaffolds can lead to complications.
  • Needle-syringe injection offers a less invasive alternative for scaffold delivery.

Purpose of the Study:

  • To develop injectable, macroporous scaffolds with shape-memory properties.
  • To evaluate the injectability and structural integrity of these scaffolds post-injection.
  • To assess the potential of these scaffolds for in vivo biomolecule delivery and cell therapy applications.

Main Methods:

  • Preparation of injectable 3D scaffolds using environmentally friendly cryotropic gelation of a natural polymer.
  • Characterization of scaffold properties, including elasticity, shape-memory behavior, and deformability.
  • Assessment of in vivo biomolecule release and cell retention/engraftment following injection.

Main Results:

  • Elastic, sponge-like cryogel scaffolds with shape-memory properties were successfully prepared.
  • Scaffolds demonstrated over 90% reversible deformation and rapid volumetric recovery after needle injection.
  • In vivo studies showed long-term biomolecule release and enhanced cell survival, retention, and engraftment compared to standard injection.

Conclusions:

  • Injectable, shape-memory macroporous scaffolds can be fabricated from natural polymers via cryotropic gelation.
  • These scaffolds enable minimally invasive delivery with excellent structural integrity and recovery.
  • The developed injectable scaffolds show significant potential for advanced biomedical applications, particularly in cell therapies.