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Published on: April 21, 2013
Electronic sensor and actuator webs for large-area complex geometry cardiac mapping and therapy
Dae-Hyeong Kim1, Roozbeh Ghaffari, Nanshu Lu
1Center for Nanoparticle Research of Institute for Basic Science, World Class University Program of Chemical Convergence for Energy and Environment, School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742, Korea.
Summary
Researchers developed large-area, stretchable sensor webs that conform to the heart
Area of Science:
- Biomedical Engineering
- Materials Science
Background:
- Cardiac device interfaces face challenges due to heart's complex geometry and motion.
- Current methods often require sutures or adhesives, risking tissue damage and poor contact.
Purpose of the Study:
- To create large-area, conformable, and non-constraining interfaces for cardiac applications.
- To develop multifunctional sensor and actuator webs for diagnostics and therapeutics.
Main Methods:
- Designed stretchable sensor/actuator webs with open mesh layouts.
- Mounted webs on bio-resorbable silk sheets for handling and low mechanical profile.
- Tested in vivo in rabbit and pig models.
Main Results:
- Achieved conformal epicardial wrapping without sutures or adhesives.
- Demonstrated effective measurement of temperature, electrophysiological signals, and strain.
- Showcased potential for localized tissue ablation delivery.
Conclusions:
- Developed a novel approach for large-area, intimate cardiac device integration.
- These webs offer a versatile platform for cardiac monitoring and therapy.
- The bio-resorbable silk substrate enhances device conformability and biocompatibility.
