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Updated: May 16, 2026

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
Published on: August 19, 2012
Difluoro-C4'-oxidized abasic site for efficient amine modification in biological systems
Bo Yang1, Akiko Jinnouchi, Hiroshi Suemune
1Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Abstract:
An oligodeoxynucleotide (ODN) containing a 2',2'-difluorinated analogue of a C4'-oxidized abasic site (C4'-OAS) was designed for the amine modification of biomolecules that interact with nucleic acids. In contrast to the parent C4'-OAS, which yielded amine-modified products accompanied by DNA strand scission, the ODN containing the difluoro C4'-OAS efficiently yielded products carrying ODNs. The amine modification proceeded without additional reagents being required and might be applicable to reactions in biological systems.
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